Reply to Davis: Nitric Oxide Regulates Lymphatic Contractions

Christian Kunert; James W. Baish; Shan Liao; Timothy P Padera; Lance L Munn

Reply to Davis: Nitric Oxide Regulates Lymphatic Contractions

Christian Kunert, James W. Baish, Shan Liao, Timothy P Padera, Lance L Munn

Bucknell University

Massachusetts General Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

We appreciate the opportunity to respond to Michael J. Davis’s Letter (1) regarding our paper “Mechanobiological Oscillators Control Lymph Flow” (2). Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors—in addition to NO—affect lymphatic baseline diameter, including inflammatory cytokines and hormones, and the mechanical properties of the surrounding tissue. On the other hand, there are few mechanisms that operate at the short timescales required for the phasic contractions. Our simulations show that NO and Ca2+ are sufficient to drive these phasic contractions and that mechanobiological regulation of their levels provides intrinsic feedback …

Original language	American English
Journal	Default journal
Volume	113
State	Published - Jan 1 2016

Disciplines

Biomechanics and Biotransport

Cite this

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title = "Reply to Davis: Nitric Oxide Regulates Lymphatic Contractions",

abstract = " We appreciate the opportunity to respond to Michael J. Davis\’s Letter (1) regarding our paper \“Mechanobiological Oscillators Control Lymph Flow\” (2). Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors\—in addition to NO\—affect lymphatic baseline diameter, including inflammatory cytokines and hormones, and the mechanical properties of the surrounding tissue. On the other hand, there are few mechanisms that operate at the short timescales required for the phasic contractions. Our simulations show that NO and Ca2+ are sufficient to drive these phasic contractions and that mechanobiological regulation of their levels provides intrinsic feedback \… ",

author = "Christian Kunert and Baish, \{James W.\} and Shan Liao and Padera, \{Timothy P\} and Munn, \{Lance L\}",

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AU - Kunert, Christian

AU - Baish, James W.

AU - Liao, Shan

AU - Padera, Timothy P

AU - Munn, Lance L

PY - 2016/1/1

Y1 - 2016/1/1

N2 - We appreciate the opportunity to respond to Michael J. Davis’s Letter (1) regarding our paper “Mechanobiological Oscillators Control Lymph Flow” (2). Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors—in addition to NO—affect lymphatic baseline diameter, including inflammatory cytokines and hormones, and the mechanical properties of the surrounding tissue. On the other hand, there are few mechanisms that operate at the short timescales required for the phasic contractions. Our simulations show that NO and Ca2+ are sufficient to drive these phasic contractions and that mechanobiological regulation of their levels provides intrinsic feedback …

AB - We appreciate the opportunity to respond to Michael J. Davis’s Letter (1) regarding our paper “Mechanobiological Oscillators Control Lymph Flow” (2). Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors—in addition to NO—affect lymphatic baseline diameter, including inflammatory cytokines and hormones, and the mechanical properties of the surrounding tissue. On the other hand, there are few mechanisms that operate at the short timescales required for the phasic contractions. Our simulations show that NO and Ca2+ are sufficient to drive these phasic contractions and that mechanobiological regulation of their levels provides intrinsic feedback …

UR - https://digitalcommons.bucknell.edu/fac_journ/1326

M3 - Article

VL - 113

JO - Default journal

JF - Default journal

ER -

Reply to Davis: Nitric Oxide Regulates Lymphatic Contractions

Abstract

Disciplines

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